Am I right in thinking it's PAN141A.SSD for drive 0 and PAN141B.SSD for drive 2?
Yes, that's correct.
If so, still no joy with exactly the same symptom as before - Panos starts to load but the system hangs.
Hmm, that's a shame. Are you able to connect the serial console and see if there's any debug output.
I've removed the ADFS 1.33/1.53 ROM and will now see if I can remove the DFS ROM. The Beeb is a B+64K
You are the first person I'm aware of to try PiTubeDirect on a B+64K. I wonder if there are some issues peculiar to this host. The Tube is buffered by LS244/LS245 TTL chips, so the timing may be slightly different. I would hope we were not that marginal.
Have you tried any of the other Co Processors, e.g. the 80x86 booting DOSPlus?